Linked Life Data

2759661

Source:http://linkedlifedata.com/resource/pubmed/id/2759661

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-9-8
pubmed:abstractText
A small cell surface antigen of Streptococcus mutans was partially sequenced and the amino terminal peptides of 11, 15 and 20 amino acid residues and a dimer of the 15 and 20 residues peptides were synthesized. The synthetic peptides (SP) were used in topical oral immunization of the gingivomucosal epithelium of macaque monkeys. Sequential examination for antibodies over a period of up to 30 weeks revealed that six applications of the linear or cyclized SP11 and a random SP11 induced negligible or very low antibody levels. In contrast, the SP17 (SP15 with added cysteine at each terminus), SP21 (SP20 with one cysteine) and the dimer (SP35) induced significant anti-SP as well as anti-native streptococcal antibodies in the gingival fluid and in saliva. The functional significance of this immune response was examined by studying its effect on oral colonization of S. mutans following feeding of a carbohydrate-rich diet. Whereas control animals, sham-immunized with a random SP of 11 residues, showed increased colonization of the teeth by S. mutans, there was no colonization or a significant reduction in colonization of animals immunized with the cyclized SP17, linear SP21 or dimerized SP35. These experiments suggest that local immunization with SP derived from the sequences of a streptococcal cell surface antigen induce a dual local immune response of gingival IgG and salivary IgA antibodies against the SP and native SA. These antibodies may be involved in preventing colonization of S. mutans, which is the principal agent in the development of dental caries.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-1121322, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-121536, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-1273589, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-2581533, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-273396, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-3710580, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-404427, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-5283934, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-6197355, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-641151, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-6687410, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-6862630, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-7023762, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-7263636, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-7309233, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-742482, http://linkedlifedata.com/resource/pubmed/commentcorrection/2759661-765622
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Local oral immunization with synthetic peptides induces a dual mucosal IgG and salivary IgA antibody response and prevents colonization of Streptococcus mutans.
pubmed:affiliation
Department of Immunology, United Medical School of Guy's Hospital, London, U.K.
pubmed:publicationType
Journal Article