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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-9-19
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pubmed:abstractText |
Eighteen patients with lepromatous leprosy (LL) showed a significant reduction (P less than 0.001) of Langerhans cells (LC) irrespective of whether the biopsies were obtained from involved (398 +/- 186) or healthy skin (304 +/- 98). The cells showed morphological changes consisting mainly of loss of dendritic processes. Twenty-four controls (age, sex and race matched) had a mean number of LC of 632 +/- 138. In tuberculoid patients (TT) significant differences were observed, depending on the site of biopsy. Nine biopsies from involved skin had 993 +/- 206 LC, whereas 11 from healthy skin had 448 +/- 96 (P less than 0.001). This difference was confirmed in six additional borderline tuberculoid (BT) and TT patients in whom biopsies were simultaneously obtained from involved (973 +/- 179) and uninvolved skin (498 +/- 99). In 10 patients with indeterminate leprosy the LC density did not differ from the control population (630 +/- 261). The expression of LC numbers in BT and TT patients may represent migration of these cells from healthy skin to involved areas or mobilization of a central pool. The low density found in LL patients could interfere with adequate presentation of mycobacterial antigens leading to tolerance. Alternatively the presence of T helper cells in TT infiltrates may produce factors that recruit LC; their absence in LL lesions may account for the decrease in LC expression.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-0963
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-26
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2757953-Adolescent,
pubmed-meshheading:2757953-Adult,
pubmed-meshheading:2757953-Cell Count,
pubmed-meshheading:2757953-Female,
pubmed-meshheading:2757953-Humans,
pubmed-meshheading:2757953-Langerhans Cells,
pubmed-meshheading:2757953-Leprosy, Lepromatous,
pubmed-meshheading:2757953-Leprosy, Tuberculoid,
pubmed-meshheading:2757953-Male,
pubmed-meshheading:2757953-Middle Aged
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pubmed:year |
1989
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pubmed:articleTitle |
Differential expression of Langerhans cells in the epidermis of patients with leprosy.
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pubmed:affiliation |
Division of Dermatology, University of California, San Diego School of Medicine, California.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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