| pubmed-article:2756937 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C0200555 | lld:lifeskim |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C0456984 | lld:lifeskim |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C0011945 | lld:lifeskim |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:2756937 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:2756937 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2756937 | pubmed:dateCreated | 1989-8-28 | lld:pubmed |
| pubmed-article:2756937 | pubmed:abstractText | Patients on chronic hemodialysis who are treated with reusable dialyzers sterilized with formaldehyde are known to have antibodies develop with N-like specificity. These sera have been shown to also react with formaldehyde-treated N-negative cells. This latter specificity has been referred to as antiformaldehyde (anti-Form). Because anti-Form develops presumably in response to formaldehyde-treated cells that gain access to the patient's circulation, the authors reasoned that recipient anti-Form once established might be capable of binding to cells exposed to formaldehyde during dialysis, resulting in a positive direct antiglobulin test (DAT) result and an eluate reacting only with formaldehyde-treated reagent cells. The authors studied 96 patients on chronic hemodialysis who were exposed to formaldehyde-sterilized equipment. Both anti-N-like and anti-Form specificities were found. Anti-Form was detected in the serum of 16% of patients when tested against 0.37% (w/v) formaldehyde-treated cells. Nineteen percent of patients demonstrated a positive DAT result. The presence of a positive DAT result was significantly associated with the presence of anti-Form in the patient's serum (P less than 0.05). Red blood cell eluates from two patients with a positive IgG DAT result and serum anti-Form demonstrated anti-Form in the eluate. Increasing the concentration of formaldehyde treatment of red blood cells resulted in increasing strength of reactions with anti-Form serum, suggesting that the sensitivity of serum and eluate testing could be modified by the method of cell preparation. As expected, the reactivity of anti-Form with formaldehyde-treated cells could not be neutralized by formaldehyde. The authors conclude that patients treated with formaldehyde-sterilized reusable dialysis equipment may on occasion have a positive DAT result and have an eluate that is nonreactive with the use of standard reagent cells but reactive with formaldehyde-treated cells. | lld:pubmed |
| pubmed-article:2756937 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2756937 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756937 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2756937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2756937 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2756937 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2756937 | pubmed:issn | 0002-9173 | lld:pubmed |
| pubmed-article:2756937 | pubmed:author | pubmed-author:FreyGG | lld:pubmed |
| pubmed-article:2756937 | pubmed:author | pubmed-author:DarlingC ACA | lld:pubmed |
| pubmed-article:2756937 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2756937 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:2756937 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2756937 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2756937 | pubmed:pagination | 214-7 | lld:pubmed |
| pubmed-article:2756937 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2756937 | pubmed:meshHeading | pubmed-meshheading:2756937-... | lld:pubmed |
| pubmed-article:2756937 | pubmed:meshHeading | pubmed-meshheading:2756937-... | lld:pubmed |
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| pubmed-article:2756937 | pubmed:meshHeading | pubmed-meshheading:2756937-... | lld:pubmed |
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| pubmed-article:2756937 | pubmed:meshHeading | pubmed-meshheading:2756937-... | lld:pubmed |
| pubmed-article:2756937 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2756937 | pubmed:articleTitle | Positive direct antiglobulin test result in dialysis patients resulting from antiformaldehyde antibodies. | lld:pubmed |
| pubmed-article:2756937 | pubmed:affiliation | Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts 02215. | lld:pubmed |
| pubmed-article:2756937 | pubmed:publicationType | Journal Article | lld:pubmed |
