Linked Life Data

2754611

Source:http://linkedlifedata.com/resource/pubmed/id/2754611

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-8-28
pubmed:abstractText
RNA viruses are renowed for their genetic variability. The human immunodeficiency viruses (HIV) are no exception. A rapid method has been established for the genetic identification and differentiation of viral strains based on the sequencing of many M13 clones of gene-amplified products. Some isolates are internally relatively homogeneous while others are heterogeneous. There was no correlation between virus complexity and disease stage. One isolate was in fact a mixture of two distinct strains. A strong preference for G----A base substitutions was observed. These data indicate that HIV isolates cannot be described in simple molecular terms and should rather be considered as quasispecies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0894-9255
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
344-52
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
HIV-1 isolates are rapidly evolving quasispecies: evidence for viral mixtures and preferred nucleotide substitutions.
pubmed:affiliation
Laboratorie de Biologie et Immunologie Molécularies des Rétrovirus, Institut Pasteur, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't