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pubmed-article:2753357pubmed:abstractTextMutations in the amiA locus of the Gram-positive bacterium Streptococcus pneumoniae confer a complex phenotype including resistance to various antineoplastic drugs. As a first step towards the understanding of the molecular organization and the function(s) of this locus, we have cloned DNA fragments carrying its 5'- and 3'-extremities. We have isolated and characterized a down-promoter mutation and have located the functional limits of the locus. The amiA locus is between 5.8 and 7.5 kb long strongly suggesting that it encodes several proteins.lld:pubmed
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pubmed-article:2753357pubmed:authorpubmed-author:ClaverysJ PJPlld:pubmed
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pubmed-article:2753357pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:2753357pubmed:year1989lld:pubmed
pubmed-article:2753357pubmed:articleTitleCloning of the amiA locus of Streptococcus pneumoniae and identification of its functional limits.lld:pubmed
pubmed-article:2753357pubmed:affiliationCentre de Recherche de Biochimie et de Génétique Cellulaires du CNRS, Université Paul Sabatier, Toulouse, France.lld:pubmed
pubmed-article:2753357pubmed:publicationTypeJournal Articlelld:pubmed
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