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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-9-1
|
| pubmed:abstractText |
Mutations in the amiA locus of the Gram-positive bacterium Streptococcus pneumoniae confer a complex phenotype including resistance to various antineoplastic drugs. As a first step towards the understanding of the molecular organization and the function(s) of this locus, we have cloned DNA fragments carrying its 5'- and 3'-extremities. We have isolated and characterized a down-promoter mutation and have located the functional limits of the locus. The amiA locus is between 5.8 and 7.5 kb long strongly suggesting that it encodes several proteins.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0378-1119
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
76
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
363-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2753357-Aminopterin,
pubmed-meshheading:2753357-Antineoplastic Agents,
pubmed-meshheading:2753357-Cloning, Molecular,
pubmed-meshheading:2753357-DNA, Bacterial,
pubmed-meshheading:2753357-Drug Resistance, Microbial,
pubmed-meshheading:2753357-Genes, Bacterial,
pubmed-meshheading:2753357-Mutation,
pubmed-meshheading:2753357-Plasmids,
pubmed-meshheading:2753357-Promoter Regions, Genetic,
pubmed-meshheading:2753357-Restriction Mapping,
pubmed-meshheading:2753357-Streptococcus pneumoniae
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Cloning of the amiA locus of Streptococcus pneumoniae and identification of its functional limits.
|
| pubmed:affiliation |
Centre de Recherche de Biochimie et de Génétique Cellulaires du CNRS, Université Paul Sabatier, Toulouse, France.
|
| pubmed:publicationType |
Journal Article
|