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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-9-7
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pubmed:abstractText |
A cDNA clone for the human SmB and B' auto-immune antigens has been isolated by antibody screening of a cDNA expression library. The cDNA clone hybridises with two distinct mRNAs, one of which is expressed in a tissue-specific manner. A fusion protein expressed from the cDNA clone was recognised by a number of sera from systemic lupus erythematosus (SLE) patients containing anti-Sm antibodies but not by sera reactive with other auto-immune antigens. The potential use of this clone in a diagnostic assay for SLE and in elucidating the processes regulating the expression of SmB and B' is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
250
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2753153-Amino Acid Sequence,
pubmed-meshheading:2753153-Animals,
pubmed-meshheading:2753153-Antibodies, Monoclonal,
pubmed-meshheading:2753153-Autoantigens,
pubmed-meshheading:2753153-Base Sequence,
pubmed-meshheading:2753153-Blotting, Northern,
pubmed-meshheading:2753153-Blotting, Western,
pubmed-meshheading:2753153-DNA,
pubmed-meshheading:2753153-Gene Expression Regulation,
pubmed-meshheading:2753153-Humans,
pubmed-meshheading:2753153-Lupus Erythematosus, Systemic,
pubmed-meshheading:2753153-Mice,
pubmed-meshheading:2753153-Molecular Sequence Data,
pubmed-meshheading:2753153-Nucleic Acid Hybridization,
pubmed-meshheading:2753153-RNA, Messenger,
pubmed-meshheading:2753153-Recombinant Fusion Proteins
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pubmed:year |
1989
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pubmed:articleTitle |
Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera.
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pubmed:affiliation |
Medical Molecular Biology Unit, University College, London, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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