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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-8-29
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pubmed:abstractText |
The combinations of tricyclodecan-9-yl-xanthogenate (D 609) with undecanoic acid (C11) and D 609 with myristic acid (C14) were tested in 3 rodent tumor models in vivo. D 609 in combination with C11 or C14 did not show antitumoral efficacy in 3-Lewis lung carcinoma (3-LL) growing in syngeneic C57BL6-mice (primary tumor and metastasis) or in WEHI-3B myelomonocytic leukemia growing in Balb/c mice, when given in a dose range lower than the lethal dose for 10% of the treated animals (LD10). In L 1210 mouse lymphoid leukemia growing in CD2F1 mice the combination of D 609/C11 given intraperitoneally in a concentration of 100 mg/kg for more than 1 day effected a significant difference in the survival curves between the control and therapeutic groups in 1 out of 2 experiments. In conclusion, the treatment schedules of D 609/C11 or D 609/C14 used in this study has not revealed significant therapeutic effects in mouse tumors or leukemias in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-52
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:2752384-Animals,
pubmed-meshheading:2752384-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2752384-Bridged Compounds,
pubmed-meshheading:2752384-Fatty Acids,
pubmed-meshheading:2752384-Female,
pubmed-meshheading:2752384-Leukemia, Experimental,
pubmed-meshheading:2752384-Leukemia L1210,
pubmed-meshheading:2752384-Lung Neoplasms,
pubmed-meshheading:2752384-Mice,
pubmed-meshheading:2752384-Mice, Inbred BALB C,
pubmed-meshheading:2752384-Mice, Inbred C57BL,
pubmed-meshheading:2752384-Myristic Acids,
pubmed-meshheading:2752384-Neoplasms, Experimental,
pubmed-meshheading:2752384-Thiones
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pubmed:year |
1989
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pubmed:articleTitle |
Antitumoral activity of a xanthate compound. II. Therapeutic studies in murine leukemia and tumor models in vivo.
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pubmed:affiliation |
Department of Medicine I, Technische Universität, Munich, F.R.G.
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pubmed:publicationType |
Journal Article
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