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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-8-29
|
| pubmed:abstractText |
Two alpha-globin structural mutants were mapped to their encoding loci by in vitro translation of hybrid-selected alpha 1- and alpha 2-globin mRNA. The more highly expressed mutant, alpha Spanish Town (alpha 27Val), is encoded at the alpha 2 locus and the less expressed mutant, alpha Fort de France (alpha 45Arg), is encoded at the alpha 1 locus. These results further define the distribution of alpha-globin structural mutations within the alpha-globin gene cluster and substantiate the dominant role of the alpha 2-globin locus in alpha-globin expression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
833-5
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2752146-Amino Acid Sequence,
pubmed-meshheading:2752146-Arginine,
pubmed-meshheading:2752146-Genes,
pubmed-meshheading:2752146-Globins,
pubmed-meshheading:2752146-Humans,
pubmed-meshheading:2752146-Mutation,
pubmed-meshheading:2752146-Protein Biosynthesis,
pubmed-meshheading:2752146-RNA, Messenger,
pubmed-meshheading:2752146-Thalassemia,
pubmed-meshheading:2752146-Valine,
pubmed-meshheading:2752146-West Indies
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Locus assignment of two alpha-globin structural mutants from the Caribbean basin: alpha Fort de France (alpha 45 Arg) and alpha Spanish Town (alpha 27 Val).
|
| pubmed:affiliation |
Howard Hughes Medical Institute, Department of Human Genetics, Philadelphia, PA 19104-6072.
|
| pubmed:publicationType |
Journal Article
|