Linked Life Data

2747855

Source:http://linkedlifedata.com/resource/pubmed/id/2747855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-8-22
pubmed:abstractText
Bovine adrenal medullary cells released significant amounts of opioid pentapeptides (Methionine- and Leucine-enkephalin), when stimulated with neuropeptides like angiotensin II (AT), bradykinin (BK) or neurotensin (NT). Dose-response curves for angiotensin II and bradykinin were shown to be double-sigmoidal, with the first EC50 in the nM range; much lower than that for acetylcholine, nicotine or histamine. Secretory effects were dependent on extracellular CA++ and impaired by the Ca++ channel blockers D600. Moreover, these peptides produced an increase in opioid peptide cell content after 48 h of incubation, as did nicotine-, histamine- and K+ treated cells. The compound's capacity to induce long-term Met-enk secretion was similar to their efficacy in raising intracellular opioid peptide levels, suggesting compensatory increases. Besides affecting opioid peptide metabolism, AT, BK and NT produced a significant accumulation of inositol-1-phosphates (IP1), the role of which remains to be clarified. The physiological significance of vasoactive compounds in the adrenal medulla will be discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0143-4179
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-51
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Neuropeptides and other secretagogues in bovine chromaffin cells: their effect on opioid peptide metabolism.
pubmed:affiliation
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Martinsried, Federal Republic of Germany.
pubmed:publicationType
Journal Article