Linked Life Data

2746654

Source:http://linkedlifedata.com/resource/pubmed/id/2746654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-21
pubmed:abstractText
The effects of the glycoside saponin on ferret ventricular muscle have been investigated. Saponin produced a positive inotropic effect, the extent of which was determined by the bathing calcium concentration. If the bathing calcium concentration is reduced to levels equivalent to those found intracellularly then similar saponin concentrations are able to "skin" the cardiac cells. The effects were further investigated in sheep heart Purkinje fibres. In the presence of normal extracellular calcium concentrations (to prevent skinning), saponin produced increases in sodium activity, decreases in potassium activity but little change in intracellular pH. The decreases of potassium activity were compared to the effects of strophanthidin. The changes in intracellular ion levels were accompanied by the development of a contracture. The effects of saponin could be explained by its interaction with cholesterol in the cell membrane resulting in an increase in membrane permeability to sodium which may be part of a nonspecific increase in membrane permeability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of saponin on contractile force and intracellular ion activities of cardiac tissues.
pubmed:affiliation
Department of Physiology, University Medical School, Edinburgh, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't