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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1989-8-11
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pubmed:abstractText |
Newcastle disease virus (NDV) infection in chickens differing in vitamin A status has been selected as a model to examine the interrelationship between marginal vitamin A deficiency and the severity of consequences of measles infection in humans. Day-old chickens with limited vitamin A reserves, the progeny of marginally vitamin A-deficient hens, were fed purified diets containing either marginal (120 retinol equivalents/kg diet, ad libitum) or adequate (1200 retinol equivalents/kg diet, ad libitum or pair-fed) levels of vitamin A for a period of 10 wk. At 4 wk of age, half of the chickens in each group were infected intraocularly with the lentogenic, i.e., mildly pathogenic, La Sota strain of NDV. Within 1 wk of infection, plasma retinol levels in the infected, marginally vitamin A-deficient chickens showed a significant and persistent decrease compared to their noninfected counterparts fed the same diet. Moreover, infection with NDV resulted in increased rates of morbidity in the marginally vitamin A-deficient chickens compared with nondeficient chickens. The results of this study indicate that pre-existing marginal vitamin A status increases the severity of disease following NDV infection, and that infection with NDV reduces marginal plasma vitamin A levels to levels which can be regarded as deficient.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3166
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
932-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2746374-Animals,
pubmed-meshheading:2746374-Body Weight,
pubmed-meshheading:2746374-Chickens,
pubmed-meshheading:2746374-Diet,
pubmed-meshheading:2746374-Disease Models, Animal,
pubmed-meshheading:2746374-Eating,
pubmed-meshheading:2746374-Female,
pubmed-meshheading:2746374-Newcastle Disease,
pubmed-meshheading:2746374-Serum Albumin,
pubmed-meshheading:2746374-Time Factors,
pubmed-meshheading:2746374-Vitamin A,
pubmed-meshheading:2746374-Vitamin A Deficiency
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pubmed:year |
1989
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pubmed:articleTitle |
The interaction between vitamin A status and Newcastle disease virus infection in chickens.
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pubmed:affiliation |
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study
|