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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-8-18
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pubmed:abstractText |
Heparin stimulates 2-3-fold, in a concentration-dependent manner, the synthesis of heparan sulfate secreted by cultured endothelial cells. The increase in synthetic rate takes place immediately after exposure of the cells to heparin, affects only heparan sulfate, and is specific for the endothelial cell. No stimulation by other glycosaminoglycans was observed. Analysis of the disaccharide products formed by the action of heparitinases reveals a higher degree of sulfation of the uronic acid residues in the heparan sulfate of cells exposed to heparin.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9541
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-10
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2745565-Animals,
pubmed-meshheading:2745565-Cattle,
pubmed-meshheading:2745565-Cells, Cultured,
pubmed-meshheading:2745565-Chemical Phenomena,
pubmed-meshheading:2745565-Chemistry,
pubmed-meshheading:2745565-Electrophoresis, Agar Gel,
pubmed-meshheading:2745565-Endothelium, Vascular,
pubmed-meshheading:2745565-Glycosaminoglycans,
pubmed-meshheading:2745565-Heparin,
pubmed-meshheading:2745565-Heparitin Sulfate,
pubmed-meshheading:2745565-Proteoglycans
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pubmed:year |
1989
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pubmed:articleTitle |
Heparin stimulates the synthesis and modifies the sulfation pattern of heparan sulfate proteoglycan from endothelial cells.
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pubmed:affiliation |
Departamento de Bioquimica, Escola Paulista de Medicina, São Paulo, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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