Linked Life Data

2745526

Source:http://linkedlifedata.com/resource/pubmed/id/2745526

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-17
pubmed:abstractText
For the clinical follow-up of endothelial cell seeded grafts, non-invasive but sensitive parameters are required in order to determine the extent and effectiveness of the endothelialization process. Such a very sensitive parameter was found by investigating the surface morphology of circulating platelets. This technique is based on the previous observation that characteristic alterations of platelet morphology are closely associated with the course of the aggregometer tracings. Applying these ultrastructural criteria we investigated 16 patients after distal femoro-popliteal and femoro-crural bypass surgery. Reinforced 6 mm non-seeded PTFE vascular grafts were compared with reversed autologous saphenous vein grafts. As early as 4 hours after graft implantation, a significant higher percentage of discoid platelets with marginal pseudopods--representing the earliest stage of platelet activation--as well as of spheroid "shape changed" platelets was found in patients with PTFE grafts. Moreover, perforated platelet membranes were exclusively found in the PTFE group. These findings were most distinguished 10 days postoperatively but persisted over the follow-up period of 1 year. Considering the sensitivity of the described technique it might provide a simple, reliable, and non-invasive means for the clinical assessment of successful graft endothelialization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-9509
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
398-401
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:articleTitle
Surface morphology of circulating platelets: a suggested parameter for the monitoring of endothelial seeded grafts.
pubmed:affiliation
Department of Surgery 2, University of Vienna, Austria.
pubmed:publicationType
Journal Article, Comparative Study