Linked Life Data

2744326

Source:http://linkedlifedata.com/resource/pubmed/id/2744326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 1
pubmed:dateCreated
1989-8-14
pubmed:abstractText
An ultrastructural analysis was carried out on duodenal mucosa specimens, obtained during duodenoscopy from the edge of ulcers and distal duodenal cap mucosa in 42 patients with active duodenal ulcer disease, and in 12 controls. In 18 of 42 patients (43 p. 100), Campylobacter pylori was found in duodenal mucosa but not in controls (chi 2 = 5.91, p less than 0.05). In all 42 cases, gastric-type surface mucus cells were seen at the edge of the ulcer crater, and in 38 of the patients (90 p. 100) these metaplastic cells were also seen in the distal duodenal cap. C. pylori was always localized within the mucus layer, frequently in the intercellular spaces and, in 4 of 18 cases (22 p. 100), within the cytoplasm. C. pylori was detected exclusively in the proximity of gastric type metaplastic surface mucus cells with apparent fusion of membranes. It is suggested that the metaplastic surface mucus cell in the duodenal epithelium of patients with active duodenal ulcer disease is the target cell for colonization by C. pylori.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0399-8320
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71B-74B
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Gastric metaplasia and Campylobacter pylori in duodenal ulcer disease: an ultrastructural analysis.
pubmed:affiliation
Department of Internal Medicine II, University of Ulm, FRG.
pubmed:publicationType
Journal Article