Linked Life Data

2742588

Source:http://linkedlifedata.com/resource/pubmed/id/2742588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-8
pubmed:abstractText
The effect of estradiol on the acetylation of nuclear high mobility group (HMG) proteins in the uterus of newborn (3 days old) guinea pigs was studied "in vivo" and in tissue slices. In the "in vivo" studies after subcutaneous injection of 5 mCi [3H]-acetate there is a rapid (20 min) uptake of radioactive acetate in the HMG-1, HMG-2, HMG-14 and HMG-17 high mobility group proteins. In parallel studies, after administration of the same quantity of [3H]-acetate plus 20 micrograms of estradiol (E2), a selective increase in the acetylation of HMG-14 protein is observed. The preferential acetylation of HMG-14 can also be demonstrated in uterine tissue slices 20 minutes after exposure to the hormone (5 x 10(-8)M). In conclusion, the present data suggest that the acetylation of HMG proteins, in particular HMG-14, and like that of nucleosomal "core" histones, is an early event in gene activation by estradiol.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1260-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Estradiol enhanced acetylation of nuclear high mobility group proteins of the uterus of newborn guinea pigs.
pubmed:affiliation
C.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't