Linked Life Data

2742578

Source:http://linkedlifedata.com/resource/pubmed/id/2742578

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-8
pubmed:abstractText
We report the initial characterization of pp64, a nuclear protein recognized by anti-PDGF antisera and uniquely phosphorylated when intact NRK fibroblasts were exposed to PDGF. Neither DNase nor RNase released pp64 from nuclei and pp64 was only partially extracted from nuclei of NRK cells with NaCl; detergents were required for complete extraction. The estimated half-life of pp64 from normal and transformed NRK cells was approximately 6 hrs. The rapid and unique PDGF stimulated phosphorylation of pp64 identifies a previously uncharacterized nuclear phosphoprotein, and a potentially novel signal transduction pathway from the cell surface to the nucleus which may be important in initiating nuclear events associated with DNA synthesis and cell division.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1118-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Characterization of pp64, a nuclear phosphoprotein induced by platelet-derived growth factor.
pubmed:affiliation
Department of Medicine, Jewish Hospital, Washington 4niversity Medical Center, St. Louis, Missouri 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't