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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-8-9
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pubmed:abstractText |
During the course of prenatal diagnosis for beta-thalassemia in Chinese patients, we encountered a mutation that was not detectable by oligonucleotides for the known Chinese mutations. Amplification of the beta-globin gene by the polymerase chain reaction and direct DNA sequencing revealed a previously undescribed -30 TATA box mutation which was carried by the father. Prenatal diagnosis was achieved, and the fetus did not inherit this beta-thalassemia allele.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-2901867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-2917180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3002527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3021607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3338793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3359045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3405266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3627274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-3785382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-6308558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-6583702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2741940-7076659
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2741940-Amniocentesis,
pubmed-meshheading:2741940-Base Sequence,
pubmed-meshheading:2741940-Female,
pubmed-meshheading:2741940-Genes,
pubmed-meshheading:2741940-Globins,
pubmed-meshheading:2741940-Humans,
pubmed-meshheading:2741940-Male,
pubmed-meshheading:2741940-Molecular Sequence Data,
pubmed-meshheading:2741940-Mutation,
pubmed-meshheading:2741940-Pedigree,
pubmed-meshheading:2741940-Pregnancy,
pubmed-meshheading:2741940-Prenatal Diagnosis,
pubmed-meshheading:2741940-Promoter Regions, Genetic,
pubmed-meshheading:2741940-Thalassemia
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pubmed:year |
1989
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pubmed:articleTitle |
A new TATA box mutation detected at prenatal diagnosis for beta-thalassemia.
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pubmed:affiliation |
Department of Medicine, University of California, San Francisco 94143-0724.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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