Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1989-8-3
|
pubmed:abstractText |
Unvaccinated mice were treated with T-2 toxin either 6 days before or 1 day after exposure to aerosols of virulent Mycobacterium tuberculosis. Mice were also treated with T-2 toxin 6 days before vaccination with Mycobacterium bovis (BCG). There was a T-2 toxin mediated increase in the number of viable vaccine organisms recovered from the spleens of toxin-treated mice at 3 weeks after vaccination, and splenomegaly at post-vaccine weeks 3 through 5. At the seventh week after vaccination, toxin-treated vaccinated, toxin-treated non-vaccinated, vaccinated, and untreated mice were exposed to aerosols of viable M tuberculosis. The number of viable mycobacteria in the lungs was determined at weeks 3, 5, 7, and 9 after pulmonary infection. The number of viable tubercle bacilli recovered from the lungs of vaccinated mice was significantly lower than from unvaccinated mice. However, T-2 toxin-treatment did not alter the vaccine efficacy.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0145-6296
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
213-7
|
pubmed:dateRevised |
2003-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2741306-Animals,
pubmed-meshheading:2741306-BCG Vaccine,
pubmed-meshheading:2741306-Female,
pubmed-meshheading:2741306-Mice,
pubmed-meshheading:2741306-Mice, Inbred ICR,
pubmed-meshheading:2741306-Sesquiterpenes,
pubmed-meshheading:2741306-Spleen,
pubmed-meshheading:2741306-T-2 Toxin,
pubmed-meshheading:2741306-Tuberculosis, Pulmonary
|
pubmed:year |
1989
|
pubmed:articleTitle |
Influence of T-2 toxin on BCG vaccine efficacy against murine pulmonary tuberculosis.
|
pubmed:affiliation |
US Department of Agriculture, Veterinary Toxicology & Entomology Research Laboratory, College Station, TX 77841.
|
pubmed:publicationType |
Journal Article
|