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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1989-8-10
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pubmed:databankReference |
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pubmed:abstractText |
We analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with acute T-lymphoblastic leukemia. The chromosomal joining on the 1p+ chromosome occurred at the T-cell receptor delta diversity (D delta 2) segment, and the reciprocal chromosomal joining on the 14q- chromosome occurred at the T-cell delta diversity segment D delta 1. The involvement of delta diversity segments at the translocation junctions suggests that the translocation occurred during an attempt at D delta 1-D delta 2 joining in a stem cell. The segment of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5). The differential expression of the TCL5 RNA transcripts in this lymphohemopoietic stem cell line relative to several other T- and B-cell lines suggests that TCL5 gene expression is an integral event in the pathogenesis of the T-cell leukemia. Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-2467296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-2836865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-2953797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-2997622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3029760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3047582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3070852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3085877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3127828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3129686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3194416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3299258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3413078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3486937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3491637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3499667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3880642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3919442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-3940171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-4056659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6209808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6282683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6308654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6414084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6577466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6607471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6783961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-6982733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2740341-7139592
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5039-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2740341-Base Sequence,
pubmed-meshheading:2740341-Blotting, Southern,
pubmed-meshheading:2740341-Cell Line,
pubmed-meshheading:2740341-Chromosomes, Human, Pair 1,
pubmed-meshheading:2740341-Chromosomes, Human, Pair 14,
pubmed-meshheading:2740341-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:2740341-Genes, Immunoglobulin,
pubmed-meshheading:2740341-Humans,
pubmed-meshheading:2740341-Leukemia, T-Cell,
pubmed-meshheading:2740341-Melanoma,
pubmed-meshheading:2740341-Molecular Sequence Data,
pubmed-meshheading:2740341-Nucleic Acid Hybridization,
pubmed-meshheading:2740341-Receptors, Antigen, T-Cell,
pubmed-meshheading:2740341-Restriction Mapping,
pubmed-meshheading:2740341-Translocation, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.
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pubmed:affiliation |
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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