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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-8-1
|
| pubmed:abstractText |
Amphotericin B nephrotoxicity limits its therapeutic use. The mechanisms involved in the deleterious effect on the kidney include a preglomerular vasoconstriction. Nifedipine, a calcium antagonist which acts also on the afferent arteriolar tone, did not, however, prevent renal impairment in the rats of our study. This could be due either to a negligible role of the hemodynamic changes in the development of renal failure or to a lack of efficacy of nifedipine on the vasoconstrictor mechanism induced by amphotericin B.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-2766
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
278-80
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1989
|
| pubmed:articleTitle |
Nifedipine and amphotericin B nephrotoxicity in the rat.
|
| pubmed:affiliation |
Department of Internal Medicine, Erasmus University Hospital, Belgium.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|