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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1989-8-4
|
| pubmed:abstractText |
Syntheses of 5-deaza-5,6,7,8-tetrahydrofolic acid (7a) and its 10-formyl (7b), 10-acetyl (7c), and 10-methyl (7d) derivatives are described. These compounds, prepared as analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), the lead compound of a new class of folate antimetabolites, exhibit potent growth inhibition against leukemic cells in culture as well as substantial antitumor activity against transplantable murine solid tumors in vivo.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1517-22
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2738886-Animals,
pubmed-meshheading:2738886-Antineoplastic Agents,
pubmed-meshheading:2738886-Chemical Phenomena,
pubmed-meshheading:2738886-Chemistry,
pubmed-meshheading:2738886-Humans,
pubmed-meshheading:2738886-Leukemia L1210,
pubmed-meshheading:2738886-Mice,
pubmed-meshheading:2738886-Nitrogen,
pubmed-meshheading:2738886-Purines,
pubmed-meshheading:2738886-Tetrahydrofolates,
pubmed-meshheading:2738886-Tumor Cells, Cultured
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues.
|
| pubmed:affiliation |
Department of Chemistry, Princeton University, New Jersey 08544.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|