Linked Life Data

2737543

Source:http://linkedlifedata.com/resource/pubmed/id/2737543

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-3
pubmed:abstractText
Ring preparations of human stem villous arteries were prepared by microtechnique from placentae born after normal-term vaginal delivery. Isometric tension was recorded in organ baths. Indomethacin 10(-8)-10(-5) M left responses to K+ depolarization and contractions produced by prostaglandin F2 alpha (PGF2 alpha) unaffected, while indomethacin 10(-4) M slightly decreased K+-induced contractions and inhibited responses to PGF2 alpha. In contrast, nitrendipine 10(-9)-10(-6) M markedly decreased responses to K+ while nitrendipine 10(-8)-10(-6) M inhibited PGF2 alpha-induced responses. Relaxant responses to vasointestinal polypeptide 10(-8)-10(-7)M were left unaffected by pretreatment with indomethacin 5 X 10(-5) M. Indomethacin affects contractile activation in human stem villous arteries only in high concentrations, and the effects differ in profile from those of calcium entry blockers like nitrendipine. The results do not leave evidence for increased placental arterial tone during indomethacin treatment in pregnancy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-7346
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of indomethacin on human placental stem villous arteries.
pubmed:affiliation
Department of Obstetrics and Gynecology, University of Aarhus, Denmark.
pubmed:publicationType
Journal Article, Comparative Study