Linked Life Data

2735454

Source:http://linkedlifedata.com/resource/pubmed/id/2735454

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 2
pubmed:dateCreated
1989-7-18
pubmed:abstractText
Because plasma arginine vasopressin (AVP) levels are raised during streptozotocin (STZ)-induced diabetes mellitus (DM), it is possible that AVP contributes to the pattern of change in fluid and electrolyte handling and cardiovascular status after STZ treatment. Therefore we have made daily measurements of cardiovascular and metabolic variables in normal (Long-Evans) and AVP-deficient (Brattleboro) rats treated with saline or STZ. Twenty-four days after STZ, both strains had similar weight loss and increases in fluid intake, but the increase in food intake was greater in Long-Evans than in Brattleboro rats. After STZ, bradycardia developed in both strains, but only Brattleboro rats had reduced blood pressure. Plasma variables were measured 25 days after STZ. Packed cell volume and plasma sodium concentration were reduced in STZ-treated Long-Evans rats compared with saline-treated controls but were unchanged in STZ-treated Brattleboro rats. The results indicate that although AVP deficiency does not seriously affect the ability to maintain fluid and electrolyte balance after STZ treatment, there may be consequences for cardiovascular control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1279-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Diabetes mellitus in Brattleboro rats: cardiovascular, fluid, and electrolyte status.
pubmed:affiliation
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't