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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1989-7-21
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pubmed:abstractText |
Platelet-derived growth factor (PDGF) has been suggested to play an important role in wound healing. In this study wound fluid collected from patients after radical mastectomy was analyzed for PDGF-related factors. Analysis revealed the presence of two PDGF-related peptides of 16-17 kDa and 34-36 kDa. These PDGF-related peptides were purified by using anti-PDGF immunoaffinity techniques and found to possess both chemotactic and mitogenic activities for NIH 3T3 cells in vitro. Surprisingly, we could not detect authentic native PDGF (30 kDa) or PDGF A or B chain in any of the wound-fluid samples examined. These results indicate that PDGF-related peptides are present in normal human wound fluid, whereas PDGF A- and B-chain peptides are absent or only present in trace amounts relative to the total PDGF-related biological activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-1109560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-14494202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-211512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-2416458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-270695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-275851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-2832423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-3067188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-3511865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-3579723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-3670081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-3908487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-3941744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-6208557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-6607119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-6943570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-7017779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2734294-7061598
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4416-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2734294-Animals,
pubmed-meshheading:2734294-Blotting, Western,
pubmed-meshheading:2734294-Cells, Cultured,
pubmed-meshheading:2734294-Chemotaxis,
pubmed-meshheading:2734294-Chromatography, Affinity,
pubmed-meshheading:2734294-Female,
pubmed-meshheading:2734294-Humans,
pubmed-meshheading:2734294-Macromolecular Substances,
pubmed-meshheading:2734294-Mastectomy, Radical,
pubmed-meshheading:2734294-Mice,
pubmed-meshheading:2734294-Molecular Weight,
pubmed-meshheading:2734294-Platelet-Derived Growth Factor,
pubmed-meshheading:2734294-Wounds and Injuries
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pubmed:year |
1989
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pubmed:articleTitle |
Two peptides related to platelet-derived growth factor are present in human wound fluid.
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pubmed:affiliation |
Department of Biology, University of South Florida, Tampa 33620.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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