Linked Life Data

2734241

Source:http://linkedlifedata.com/resource/pubmed/id/2734241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-7-20
pubmed:abstractText
UV radiation can induce definitive ultrastructural and biochemical alterations in the dermis of the human skin that are independent of the aging process. We present observations on the solubility of collagen and the ratio of type III/type I collagen in skin protected from the sun (abdomen/axilla) and exposed to the sun (neck/face) in 15 subjects, together with histological and immunohistochemical data on the same subjects. The solubility of collagen in acetic acid was similar for protected and exposed skin and solubility in the pepsin-digestable fraction was not significantly altered by chronic sun damage. This indicates that UV radiation does not affect synthesis or cross-link formation of the collagen chains of the human skin in vivo. Further studies indicated that the proportion of type III collagen in pepsin-soluble fraction was not increased in actinic damage. These findings were in line with immunohistochemical studies using antibodies to type III procollagen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0108-9684
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
A biochemical and immunohistochemical study of collagen in sun-exposed and protected skin.
pubmed:affiliation
Department of Dermatology, University of Oulu, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't