Linked Life Data

2730630

Source:http://linkedlifedata.com/resource/pubmed/id/2730630

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1989-7-6
pubmed:abstractText
Red blood cells are well equipped to handle intracellular oxidative stress, their membranes are permeable to O2- and H2O2, and in this way they are important regulators of oxygen reactions occurring in their surroundings. The protective effect against reduced oxygen species - generated during the endothelial cell injury of various tissues - is attributed mainly to the glutathione metabolism of red blood cells. The blood concentration of reduced (GSH) and oxidized glutathione (GSSG) was determined by a sensitive method using glutathione reductase in experimental shock syndromes induced by paraquat toxicity, tourniquet ligature and endotoxin in rats, by bleeding and reperfusion in dogs and by transient ligature of thoracic aorta in newborn piglets. Under these conditions the concentration of GSSG was elevated and GSH was lowered, resulting in an increase in the redox ratio: [GSSG/(GSH + GSSG)] x 100 (GSSG/GSH); particularly during reperfusion. Determination of the GSSG/GSH seems to be a reliable index to assess the degree of oxidative stress "in vivo".
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S53-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
The ratio of oxidized/reduced glutathione as an index of oxidative stress in various experimental models of shock syndrome.
pubmed:affiliation
Albert Szent-Györgyi University Medical School, Department of Paediatrics, Szeged, Hungary.
pubmed:publicationType
Journal Article