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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1989-7-6
|
| pubmed:abstractText |
AWD 23-15 (6-Methyl-1,2,3,4-tetrahydro-pyrimidin-2,4 dion) which is known to improve learning and memory processes in laboratory animals, was investigated in several hypoxia models. The following results were obtained: 1. Increase of survival rate, 2. change in hypoxia-induced decrease of cerebral post-mortem adenylic energy charge and in concentrations of metabolic products in the brain and 3. antagonism of the hypoxia-induced decrease of dopamine release. However in the general behavioral test the drug was ineffective. These results support the idea that AWD 23-15 is a potential nootropic drug.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0232-766X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S247-50
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2730618-Adenine Nucleotides,
pubmed-meshheading:2730618-Animals,
pubmed-meshheading:2730618-Anoxia,
pubmed-meshheading:2730618-Brain,
pubmed-meshheading:2730618-Female,
pubmed-meshheading:2730618-Glucose,
pubmed-meshheading:2730618-Male,
pubmed-meshheading:2730618-Mice,
pubmed-meshheading:2730618-Rats,
pubmed-meshheading:2730618-Rats, Inbred Strains,
pubmed-meshheading:2730618-Reference Values,
pubmed-meshheading:2730618-Uracil
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Antihypoxic effects of AWD 23-15 in mice and rats.
|
| pubmed:affiliation |
Institute of Pharmacological Research, Berlin, GDR.
|
| pubmed:publicationType |
Journal Article
|