Linked Life Data

2730461

Source:http://linkedlifedata.com/resource/pubmed/id/2730461

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-6-28
pubmed:abstractText
Collagen is the major constituent of the in vivo extracellular matrix environment and the ability of collagen substrates to support growth of cultured cells in vitro is well recognized. The aim of the present study was to examine in vitro proliferation and matrix-binding of cells obtained from a human colon fibroblast and four colon cancer cell lines cultured in a collagen matrix environment. In contrast to colon fibroblasts, colon cancer cell lines proliferated in this culture system and their proliferative capacities were dependent upon the collagen concentration and whether tumour cells were seeded on or in the collagen. Both laminin and fibronectin stimulated growth of one of the four colon cancer cell lines without an apparent increase in cell-matrix binding. The use of collagen matrices to culture tumour cells in vitro might facilitate identification of factors which regulate growth of an individual's colorectal cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0004-8682
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
415-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Human colon cancer and fibroblast cell lines cultured in and on collagen gels.
pubmed:affiliation
Discipline of Surgical Science, University of Newcastle, New South Wales, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't