Linked Life Data

2727638

Source:http://linkedlifedata.com/resource/pubmed/id/2727638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-7-7
pubmed:abstractText
The absorption of ampicillin esters is reported to decrease when gastric acidity is inhibited because of hydrolysis of the esters, or by lowered solubility at a higher pH. No such information on the hydroxylated derivative amoxycillin is available. This was investigated in 8 fasting volunteers, who received 800 mg bacampicillin or 1000 mg amoxycillin on 4 study days, separated by at least 1 week. Each ampicillin derivative was administered on 1 occasion as a single drug, and on another after 1 week's pretreatment with the potent acid inhibitor omeprazole. Bacampicillin was absorbed more rapidly than amoxycillin, and serum peak concentrations were higher. After induced hypoacidity, peak concentrations of both antibiotics appeared to be slightly delayed, and those of bacampicillin significantly reduced. Nevertheless, both the areas under the plasma concentration curves, and the half lives of elimination of the antibiotics were unaffected. Hypoacidity as such does not reduce the bioavailability of amoxycillin or bacampicillin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0036-5548
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
No effect of omeprazole-induced hypoacidity on the bioavailability of amoxycillin or bacampicillin.
pubmed:affiliation
Department of Clinical Pharmacology, University of Lund, Sweden.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't