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rdf:type |
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lifeskim:mentions |
umls-concept:C0011980,
umls-concept:C0026809,
umls-concept:C0026845,
umls-concept:C0053428,
umls-concept:C0205263,
umls-concept:C0205307,
umls-concept:C0279023,
umls-concept:C0449432,
umls-concept:C0700323,
umls-concept:C1027431,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1542147,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1995013
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pubmed:issue |
1
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pubmed:dateCreated |
1989-7-7
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pubmed:abstractText |
Potentiating effects of beta-eudesmol on neuromuscular blockade were investigated in phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice. Pretreatment with beta-eudesmol potentiated the blocking effects of succinylcholine to a greater extent in diabetic muscles than in normal ones. This effect was saturated after 30-min pretreatment in normal muscles. Further potentiation was observed after 60-min pretreatment in diabetic muscles. These results suggest that beta-eudesmol modifies the sensitivity of diabetic mice to depolarizing blockers so that they have a higher susceptibility to these compounds.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-5198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-71
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2724701-Animals,
pubmed-meshheading:2724701-Anti-Ulcer Agents,
pubmed-meshheading:2724701-Diabetes Mellitus, Experimental,
pubmed-meshheading:2724701-Male,
pubmed-meshheading:2724701-Mice,
pubmed-meshheading:2724701-Neuromuscular Blocking Agents,
pubmed-meshheading:2724701-Phrenic Nerve,
pubmed-meshheading:2724701-Respiratory Muscles,
pubmed-meshheading:2724701-Sesquiterpenes, Eudesmane,
pubmed-meshheading:2724701-Succinylcholine,
pubmed-meshheading:2724701-Terpenes
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pubmed:year |
1989
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pubmed:articleTitle |
beta-eudesmol (a main component of Atractylodes lancea)-induced potentiation of depolarizing neuromuscular blockade in diaphragm muscles of normal and diabetic mice.
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pubmed:affiliation |
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
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pubmed:publicationType |
Journal Article
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