Linked Life Data

2724697

Source:http://linkedlifedata.com/resource/pubmed/id/2724697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-7-7
pubmed:abstractText
The effect of superior cervical ganglionectomy or long term treatment with guanethidine on the mechanical response of dilator muscle of the rat iris to several stimulants was examined. The dose-response curve for noradrenaline (NA) was significantly shifted to the left 7 days after denervation (ca. x 10) or by treatment with guanethidine (ca. x 10), but those for methoxamine (Meth) and acetylcholine (ACh) were not. Cocaine did not further sensitize the denervated muscle to NA, but it sensitized the normal muscle to an extent similar to that caused by denervation. Cocaine did not affect the sensitivity to Meth in both control and denervated muscles. The maximum response to NA decreased by about 30% or 20% after surgical or chemical denervation, respectively, while those to Meth, ACh and Ca2+ did not alter significantly. These results indicate that in the dilator muscle, the sympathetic denervation caused a purely specific supersensitivity to NA which was simply explained by a presynaptic mechanism: an impairment of the neuronal uptake process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-5198
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-29
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Decrease in neuronal uptake of noradrenaline simply explains the supersensitivity after sympathectomy in the rat iris dilator.
pubmed:affiliation
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
pubmed:publicationType
Journal Article, In Vitro