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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-7-12
|
| pubmed:abstractText |
In guinea pig ileal muscle strips, trifluoperazine (TFP) inhibited the high K+-induced contraction with an IC50 of 1.9 microM and the Ca2+-induced contraction in skinned fiber with an IC50 of 44 microM. TFP decreased the high K+-induced increase in cytoplasmic Ca2+ level at the concentration 3 microM, which did not inhibit the contraction in skinned fiber. It is suggested that the inhibitory effect of TFP on the high K+-induced contraction is mainly due to the decrease in cytoplasmic Ca2+.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-5198
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
540-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2724694-Animals,
pubmed-meshheading:2724694-Calcium,
pubmed-meshheading:2724694-Cytoplasm,
pubmed-meshheading:2724694-Guinea Pigs,
pubmed-meshheading:2724694-Ileum,
pubmed-meshheading:2724694-Male,
pubmed-meshheading:2724694-Muscle, Smooth,
pubmed-meshheading:2724694-Muscle Contraction,
pubmed-meshheading:2724694-Nifedipine,
pubmed-meshheading:2724694-Potassium Cyanide,
pubmed-meshheading:2724694-Spectrometry, Fluorescence,
pubmed-meshheading:2724694-Trifluoperazine
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
The effect of trifluoperazine on muscle tension and cytoplasmic Ca2+ level in guinea pig ileum.
|
| pubmed:affiliation |
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|