Linked Life Data

2722772

Source:http://linkedlifedata.com/resource/pubmed/id/2722772

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1989-6-30
pubmed:abstractText
An autosomal recessive mutation, termed fatty liver dystrophy (fld), can be identified in neonatal mice by their enlarged and fatty liver (Sweet, H. O., Birkenmeier, E. H., and Davisson, M. T. (1988) Mouse News Letter 81, 69). We have examined the underlying metabolic abnormalities in fld/fld mice from postnatal days 3-40. Serum and hepatic triglyceride levels were elevated 5-fold in suckling fld/fld mice compared to their +/? littermates but abruptly resolved at the suckling/weaning transition. Blot hybridization analysis of liver and intestinal RNAs revealed a liver-specific increase in apolipoprotein (apo) A-IV and C-II mRNA concentrations (100- and 6-fold, respectively) that was limited to the suckling and early weaning stages in fld/fld mice. Resolution of these differences during the weaning period could not be delayed by prolonging suckling to the 20th postnatal day nor could the mutant phenotype be elicited in young adult animals with a high fat diet. Lipoprotein lipase (LPL) activity was reduced 16-fold in the white adipose tissue of fld/fld mice until the onset of weaning. Heart activity was decreased less than 2-fold, but there were no deficits in brown adipose tissue or liver. Hepatic lipase (HL) mRNA levels and activity were significantly reduced in fld/fld livers and sera, respectively, during the suckling period. Mapping studies show the fld locus to be distinct from loci encoding LPL, HL, and apoA-IV, and those responsible for the combined lipase deficiencies in cld/cld and W/Wv mice. These data suggest that the fld mutation is associated with developmentally programmed tissue-specific defects in the neonatal expression of LPL and HL activities and provide evidence for a new regulatory locus which affects these lipase activities. This mutation could serve as a useful model for (i) analyzing the homeostatic mechanisms controlling lipid metabolism in newborn mice and (ii) understanding and treating certain inborn errors in human triglyceride metabolism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7994-8003
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:2722772-Adipose Tissue, pubmed-meshheading:2722772-Aging, pubmed-meshheading:2722772-Animals, pubmed-meshheading:2722772-Animals, Suckling, pubmed-meshheading:2722772-Apolipoprotein C-II, pubmed-meshheading:2722772-Apolipoproteins A, pubmed-meshheading:2722772-Apolipoproteins C, pubmed-meshheading:2722772-Fatty Liver, pubmed-meshheading:2722772-Hypertriglyceridemia, pubmed-meshheading:2722772-Lipase, pubmed-meshheading:2722772-Lipoprotein Lipase, pubmed-meshheading:2722772-Liver, pubmed-meshheading:2722772-Mice, pubmed-meshheading:2722772-Mice, Inbred BALB C, pubmed-meshheading:2722772-Mice, Mutant Strains, pubmed-meshheading:2722772-Mutation, pubmed-meshheading:2722772-Nucleic Acid Hybridization, pubmed-meshheading:2722772-RNA, Messenger, pubmed-meshheading:2722772-Triglycerides, pubmed-meshheading:2722772-Weaning
pubmed:year
1989
pubmed:articleTitle
The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities.
pubmed:affiliation
Department of Biochemistry, Washington University School of Medicine, St. Louis, Missouri 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't