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rdf:type |
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lifeskim:mentions |
umls-concept:C0001060,
umls-concept:C0018909,
umls-concept:C0019168,
umls-concept:C0020852,
umls-concept:C0026809,
umls-concept:C0029341,
umls-concept:C0042210,
umls-concept:C0305062,
umls-concept:C0871261,
umls-concept:C1627358,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
1989-6-23
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pubmed:abstractText |
The adjuvant activity of chemically synthesized 6-O-acylated muramyl dipeptides (MDP) was tested in aqueous form. The activity was assessed by determining immunoglobulin G (IgG) titers in sera of mice immunized with hepatitis B virus surface antigen, influenza virus hemagglutinin (HA) vaccine, or tetanus toxoid with an enzyme-linked immunosorbent assay. Administration of 6-O-acyl-MDP analogs with antigens induced marked enhancement of primary and secondary IgG antibody responses and maintained high antibody levels for at least 7 weeks. Among the analogs tested, an MDP methyl ester carrying a 6-O-3-hexadecanoyl-oxytetradecanoyl group (compound 309) exhibited the most intensive adjuvant activity. Its activity was stronger than that of 6-O-2-tetradecylhexadecanoyl (B3O)-MDP used as a positive control. However, accumulation of peritoneal cells and activation of peritoneal macrophages by compound 309 was weaker than that by 6-O-B30-MDP, suggesting that 309 as an immunoadjuvant is more suitable for vaccination in terms of its stronger enhancement of antibody formation and lower induction of inflammatory response than 6-O-B30-MDP.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-1260863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-2496044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-2844032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-313841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-3257202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-3495442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-362430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-3657794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-3744548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-6191019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-6374337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-6935684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-7010376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2722242-99814
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylmuramyl-Alanyl-Isoglutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinin Glycoproteins...,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Tetanus Toxoid
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1839-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2722242-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:2722242-Animals,
pubmed-meshheading:2722242-Antibodies, Bacterial,
pubmed-meshheading:2722242-Antibodies, Viral,
pubmed-meshheading:2722242-Cell Movement,
pubmed-meshheading:2722242-Female,
pubmed-meshheading:2722242-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:2722242-Hemagglutinins, Viral,
pubmed-meshheading:2722242-Hepatitis B Antibodies,
pubmed-meshheading:2722242-Hepatitis B Surface Antigens,
pubmed-meshheading:2722242-Immunoglobulin G,
pubmed-meshheading:2722242-Influenza Vaccines,
pubmed-meshheading:2722242-Macrophage Activation,
pubmed-meshheading:2722242-Mice,
pubmed-meshheading:2722242-Neutrophils,
pubmed-meshheading:2722242-Peritoneal Cavity,
pubmed-meshheading:2722242-Tetanus Toxoid
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pubmed:year |
1989
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pubmed:articleTitle |
Enhancement of immunoglobulin G responses in mice against hepatitis B virus surface antigen, influenza virus hemagglutinin vaccine, and tetanus toxoid by 6-O-acylated muramyl dipeptides.
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pubmed:affiliation |
School of Hygienic Sciences, Kitasato University, Sagamihara, Japan.
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pubmed:publicationType |
Journal Article
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