Linked Life Data

2721508

Source:http://linkedlifedata.com/resource/pubmed/id/2721508

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-6-30
pubmed:abstractText
In an experimental animal study using adolescent pigs we compared the pharmacokinetics and -dynamics of atropine following intravenous injection (0.25 mg, n = 6) or endobronchial instillation (2 mg, n = 6). Results showed that endobronchial atropine is rapidly absorbed by the pulmonary circulation, resulting in a peak plasma concentration of 48.8 +/- 25.9 ng ml-1 (mean +/- SD) after 2 min, compared to 46.3 +/- 16.7 ng ml-1 in the first min after intravenous injection. A first increase in heart rate could be observed within 1 min after both routes of drug administration. Significant changes in heart rate were found 9-30 min after endobronchial and 12-15 min after intravenous medication, with a maximum after 9 min (+57%) and 12 min (+24%), respectively. Mean bioavailability of atropine following the endobronchial route reached only 23% during the first 6 h when compared to intravenous administration. In light of this reduced bioavailability, we suggest an adult dosage in humans of atropine 2 mg diluted in 5-10 ml of saline administered endobronchially to attain a reliable increase in heart rate during a cardiac emergency when, in an intubated individual, no intravenous line is readily available.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0265-0215
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-101
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Comparison of intravenous and endobronchial atropine: a pharmacokinetic and -dynamic study in pigs.
pubmed:affiliation
Institute of Anaesthesiology, University of Bonn, FRG.
pubmed:publicationType
Journal Article, Comparative Study