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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-7-3
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pubmed:abstractText |
1. The cimetidine-nicoumalone interaction was studied in five subjects who received a single 10 mg oral dose of racemic nicoumalone alone and 3 days into an oral regimen of cimetidine of 200 mg three times daily and 400 mg at night. 2. The concentrations of R(+)- and S(-)-nicoumalone in plasma were measured using a stereospecific h.p.l.c assay; augmentation of prothrombin time was used as a measure of response. 3. Cimetidine increased the rate (but not extent) of absorption of both R(+)- and S(-)-nicoumalone, and reduced the clearance of R(+)-nicoumalone but not that of the S(-)-enantiomer. 4. Cimetidine increased the anticoagulant response produced by nicoumalone in some but not all subjects, despite a consistent effect on the pharmacokinetics of the oral anti-coagulant. 5. Cimetidine appears to produce its effect by stereoselectively inhibiting the elimination of R(+)-nicoumalone.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-3310029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-3408639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-3582481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-3758150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-4086582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-4830225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-6123423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-6324710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-7053283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-7249489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-7332726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-7350395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-89387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-90304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2719902-934223
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
469-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Cimetidine-nicoumalone interaction in man: stereochemical considerations.
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pubmed:affiliation |
Department of Pharmacy, University of Manchester.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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