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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1989-6-9
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pubmed:abstractText |
We compute the full harmonic vibrational spectrum and eigenmodes of a DNA oligomer, d(C-G)3, in optimized B and Z conformations in various ionic environments (0.01-5.0 M NaCl). The statistical interactions of DNA with the diffuse ionic cloud surrounding it in solution are approximately represented within the potential of mean force framework. The lowest eigenfrequency of the B conformation is found to drastically decrease with increased NaCl concentration. This suggests that a soft mode mechanism may be a precursor for the B-to-Z conversion. The free energy balance governing the B-Z isomerization of d(C-G)3 is dominated by the solvent-averaged effective phosphate-phosphate interactions due to substantial cancelations between the much larger intramolecular energy contributions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-1136898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3271454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3401554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3471112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3556586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3839596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3856228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-3863112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-4084592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-4597847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-5040245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-6305554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-6400872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-6591181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-6834428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-7150706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-7444458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2717613-861371
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3160-4
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:2717613-Anions,
pubmed-meshheading:2717613-Cations, Monovalent,
pubmed-meshheading:2717613-DNA,
pubmed-meshheading:2717613-Drug Stability,
pubmed-meshheading:2717613-Electrochemistry,
pubmed-meshheading:2717613-Hydrogen Bonding,
pubmed-meshheading:2717613-Kinetics,
pubmed-meshheading:2717613-Nucleic Acid Conformation,
pubmed-meshheading:2717613-Osmolar Concentration,
pubmed-meshheading:2717613-Polydeoxyribonucleotides,
pubmed-meshheading:2717613-Sodium Chloride,
pubmed-meshheading:2717613-Solutions,
pubmed-meshheading:2717613-Thermodynamics,
pubmed-meshheading:2717613-Vibration
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pubmed:year |
1989
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pubmed:articleTitle |
Harmonic vibrations and thermodynamic stability of a DNA oligomer in monovalent salt solution.
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pubmed:affiliation |
Theoretical Division, Los Alamos National Laboratory, NM 87545.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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