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pubmed:otherAbstract |
PIP: Blood levels of the placental protein PP12, a protein secreted in response to progesterone, were determined in 10 women having 1st trimester abortions by RU-38486 and prostaglandin. The women were all 9 weeks pregnant, and received 600 mg RU-38486 orally at 10.30 hr, followed 48 hours later by a vaginal suppository containing 1 mg 16,16- dimethyl-trans-2-PGE1 (Gemeprost, May and Baker). They were followed by ultrasound and blood was sampled hourly after RU-38486, and 2-hourly after PG. The protein PP12, assayed by radioimmunoassay, fell significantly over 4 hours after RU-38486 (p0.05), they rose to levels higher than seen initially, and fell somewhat over the 4 hours after PG administration (n.s.). All women aborted completely 2-4 hours after PG. They experienced various side effects such as moderate vaginal bleeding (2), nausea (8), vomiting (3), cramping (10) requiring analgesia (5). This study confirms that PP12 is dependent on progesterone, shows that RU-38486 directly affects the decidua, and constitutes the 1st demonstration of an anti-progesterone effect in women.
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