| pubmed-article:2714846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0033457 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0003313 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:2714846 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2714846 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2714846 | pubmed:dateCreated | 1989-6-12 | lld:pubmed |
| pubmed-article:2714846 | pubmed:abstractText | Factor D depleted serum did not support hemolysis of rabbit erythrocytes and solubilization of performed immune complexes. Fluid phase C3 cleavage increased in a dose dependent manner when D protein was added to normal or to factor D depleted serum. During short incubation factor D concentrations were correlated with the capacity of serum to solubilize immune complexes and to lyse rabbit erythrocytes. With prolonged incubation, the hemolytic activity decreased in a factor D dose dependent manner. This was probably due to fluid phase breakdown of C3 and factor B in the presence of high factor D concentrations. Hypocomplementemic sera from patients with active systemic lupus erythematosus (SLE) did not support solubilization of bovine serum albumin (BSA) anti-BSA complexes when factor D was added in excess. Patients with polycystic kidney disease with reduced renal function and high factor D concentrations showed increased concentrations of circulating C3d/dg fragments. The possibility was considered that high factor D concentrations in uremia might promote fluid phase C3 degradation and thereby limit the in vivo efficiency of alternative pathway activation on target surfaces. | lld:pubmed |
| pubmed-article:2714846 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2714846 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2714846 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2714846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2714846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2714846 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2714846 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:2714846 | pubmed:author | pubmed-author:SjöholmA GAG | lld:pubmed |
| pubmed-article:2714846 | pubmed:author | pubmed-author:SturfeltGG | lld:pubmed |
| pubmed-article:2714846 | pubmed:author | pubmed-author:TruedssonLL | lld:pubmed |
| pubmed-article:2714846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2714846 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:2714846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2714846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2714846 | pubmed:pagination | 231-6 | lld:pubmed |
| pubmed-article:2714846 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
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| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:meshHeading | pubmed-meshheading:2714846-... | lld:pubmed |
| pubmed-article:2714846 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2714846 | pubmed:articleTitle | Influence of factor D concentrations on fluid phase C3 activation, lysis of rabbit erythrocytes and solubilization of immune complexes. | lld:pubmed |
| pubmed-article:2714846 | pubmed:affiliation | Department of Rheumatology, University Hospital of Lund, Sweden. | lld:pubmed |
| pubmed-article:2714846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2714846 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
