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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-6-9
|
| pubmed:abstractText |
The kinetics of ethyl loflazepate were studied in patients with various degrees of renal failure. A strong correlation was noted between urinary excretion of metabolite loflazepate and creatinine clearance. In contrast, elimination half-life and total plasma clearance of the sum of loflazepate + descarboxyloflazepate seemed to be independent of the degree of renal impairment. These results indicate the absence of a risk of accumulation of the 2 main and active metabolites of ethyl loflazepate in patients with renal failure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0767-3981
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2714728-Administration, Oral,
pubmed-meshheading:2714728-Adult,
pubmed-meshheading:2714728-Aged,
pubmed-meshheading:2714728-Anti-Anxiety Agents,
pubmed-meshheading:2714728-Benzodiazepines,
pubmed-meshheading:2714728-Benzodiazepinones,
pubmed-meshheading:2714728-Female,
pubmed-meshheading:2714728-Humans,
pubmed-meshheading:2714728-Kidney Failure, Chronic,
pubmed-meshheading:2714728-Male,
pubmed-meshheading:2714728-Middle Aged
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Effect of renal failure on the pharmacokinetics of ethyl loflazepate (Victan) in man.
|
| pubmed:affiliation |
INSERM U 278, Faculté de Pharmacie, Marseille, France.
|
| pubmed:publicationType |
Journal Article
|