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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-6-12
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pubmed:abstractText |
In this prospective, comparative study, 129 patients who sustained penetrating abdominal trauma were randomized to receive preoperatively, and for 3-5 days postoperatively, one of three antibiotic regimens: Group I--cefotaxime (CTX) (2 Gm Q8H), Group II--cefoxitin (2 Gm Q6H), or Group III--clindamycin (900 mg Q8H) and gentamicin (3-5 mg/kg/day in divided doses Q8H). The three groups were similar in terms of the following: age, sex, severity of injury, number of organs injured, colon injuries, shock, blood transfusions, or positive intraoperative cultures. Septic complications occurred as follows: Group I--6.9%, Group II--2.3%, and Group III--6.9%. The three regimens ranked as follows in terms of therapy costs: CTX less than cefoxitin less than clindamycin and gentamicin. It is concluded that single agent therapy with a cephalosporin is preferable to combination therapy on the basis of equivalent effectiveness, lower toxicity, and lower costs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cefotaxime,
http://linkedlifedata.com/resource/pubmed/chemical/Cefoxitin,
http://linkedlifedata.com/resource/pubmed/chemical/Cephalosporins,
http://linkedlifedata.com/resource/pubmed/chemical/Clindamycin,
http://linkedlifedata.com/resource/pubmed/chemical/Gentamicins
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pubmed:status |
MEDLINE
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pubmed:issn |
0732-8893
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2714067-Adult,
pubmed-meshheading:2714067-Aged,
pubmed-meshheading:2714067-Bacterial Infections,
pubmed-meshheading:2714067-Cefotaxime,
pubmed-meshheading:2714067-Cefoxitin,
pubmed-meshheading:2714067-Cephalosporins,
pubmed-meshheading:2714067-Clindamycin,
pubmed-meshheading:2714067-Costs and Cost Analysis,
pubmed-meshheading:2714067-Drug Therapy, Combination,
pubmed-meshheading:2714067-Female,
pubmed-meshheading:2714067-Gentamicins,
pubmed-meshheading:2714067-Humans,
pubmed-meshheading:2714067-Male,
pubmed-meshheading:2714067-Middle Aged,
pubmed-meshheading:2714067-Prospective Studies,
pubmed-meshheading:2714067-Random Allocation,
pubmed-meshheading:2714067-Wounds, Penetrating
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pubmed:articleTitle |
Antibiotics for penetrating abdominal trauma: a prospective comparative trial of single agent cephalosporin therapy versus combination therapy.
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pubmed:affiliation |
Division of Trauma, Henry Ford Hospital, Detroit, Michigan 48202.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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