| pubmed-article:2713250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C0201553 | lld:lifeskim |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C1273870 | lld:lifeskim |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:2713250 | lifeskim:mentions | umls-concept:C1546922 | lld:lifeskim |
| pubmed-article:2713250 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2713250 | pubmed:dateCreated | 1989-6-15 | lld:pubmed |
| pubmed-article:2713250 | pubmed:abstractText | In 101 breast cancer patients, measurement of oestrogen receptor status in multiple biopsies across a tumour reveals a highly significant difference in the proportion of patients remaining either disease-free (P less than 0.04) or alive (P less than 0.005), when those with uniformly receptor positive (++) primary tumours are matched with clinically comparable patients whose tumours were homogeneously receptor negative (--). Mean follow-up time was 85 months. The prognostic value of this discriminant is particularly striking in the 53 patients with involved nodes at presentation. Of these, 13 were (++) and seven remain alive of whom six are disease-free, whereas 24 of the 29 (--) patients are dead. These results further suggest that receptor assay on a single homogenate gives less clinical information than do assays on multiple biopsies across the tumour. For patients with involved nodes, clinical management may best be decided after determination of 'macroheterogeneity'. | lld:pubmed |
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| pubmed-article:2713250 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2713250 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2713250 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2713250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2713250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2713250 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2713250 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:LeakeRR | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:Di CarloAA | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:MesitiMM | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:CastagnettaLL | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:CarrubaGG | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:Lo CastoMM | lld:pubmed |
| pubmed-article:2713250 | pubmed:author | pubmed-author:TrainaAA | lld:pubmed |
| pubmed-article:2713250 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2713250 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:2713250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2713250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2713250 | pubmed:pagination | 636-8 | lld:pubmed |
| pubmed-article:2713250 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2713250 | pubmed:meshHeading | pubmed-meshheading:2713250-... | lld:pubmed |
| pubmed-article:2713250 | pubmed:meshHeading | pubmed-meshheading:2713250-... | lld:pubmed |
| pubmed-article:2713250 | pubmed:meshHeading | pubmed-meshheading:2713250-... | lld:pubmed |
| pubmed-article:2713250 | pubmed:meshHeading | pubmed-meshheading:2713250-... | lld:pubmed |
| pubmed-article:2713250 | pubmed:meshHeading | pubmed-meshheading:2713250-... | lld:pubmed |
| pubmed-article:2713250 | pubmed:meshHeading | pubmed-meshheading:2713250-... | lld:pubmed |
| pubmed-article:2713250 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2713250 | pubmed:articleTitle | Do multiple oestrogen receptor assays give significant additional information for the management of breast cancer? | lld:pubmed |
| pubmed-article:2713250 | pubmed:affiliation | Hormone Biochemistry Laboratory, School of Medicine, University of Palermo-Policlinico, Italy. | lld:pubmed |
| pubmed-article:2713250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2713250 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
