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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-6-15
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pubmed:abstractText |
In 101 breast cancer patients, measurement of oestrogen receptor status in multiple biopsies across a tumour reveals a highly significant difference in the proportion of patients remaining either disease-free (P less than 0.04) or alive (P less than 0.005), when those with uniformly receptor positive (++) primary tumours are matched with clinically comparable patients whose tumours were homogeneously receptor negative (--). Mean follow-up time was 85 months. The prognostic value of this discriminant is particularly striking in the 53 patients with involved nodes at presentation. Of these, 13 were (++) and seven remain alive of whom six are disease-free, whereas 24 of the 29 (--) patients are dead. These results further suggest that receptor assay on a single homogenate gives less clinical information than do assays on multiple biopsies across the tumour. For patients with involved nodes, clinical management may best be decided after determination of 'macroheterogeneity'.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-2425942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-2874411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3015386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3524808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3595683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3606946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3663954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3893573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-3966982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-4065348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6142305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6540683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6692266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6733019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6794823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6824570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-6850609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-7088469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-7358078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-7448717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-7459239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2713250-7459240
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
636-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Do multiple oestrogen receptor assays give significant additional information for the management of breast cancer?
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pubmed:affiliation |
Hormone Biochemistry Laboratory, School of Medicine, University of Palermo-Policlinico, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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