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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-26
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pubmed:databankReference |
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pubmed:abstractText |
We mapped and sequenced three upstream exons of the chicken c-myb gene and the regions flanking the first coding exon. We found multiple potential binding sites for transcription factors in the 5'-noncoding region, a T-rich stretch of 78 base pairs (bp) (68% T) in the first intron, and four fairly long open reading frames in the antisense direction of the first coding exon and its flanking regions. Three major transcription start sites, contained within a single 11-bp region, were identified by S1 nuclease analysis and primer extension. A sequence comparison of the avian and murine c-myb genes revealed a highly conserved sequence of 124 bp in the 5'-noncoding region. Its location between the putative transcription factor binding sites and the major transcription start sites suggests that it may play an important regulatory role in c-myb expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-14582157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-226888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2413449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2423876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2441077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2452755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2821358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2828660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2831403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2831456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2834065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-2952554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3010282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3016644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3023837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3023843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3024965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3025608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3029416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3474623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3498214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3608990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-3753748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6087315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6097027,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6283631,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6313230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6327074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6504046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-6694911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2710126-7063411
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
837-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2710126-Animals,
pubmed-meshheading:2710126-Base Sequence,
pubmed-meshheading:2710126-Chickens,
pubmed-meshheading:2710126-DNA,
pubmed-meshheading:2710126-Exons,
pubmed-meshheading:2710126-Molecular Sequence Data,
pubmed-meshheading:2710126-Proto-Oncogenes,
pubmed-meshheading:2710126-Restriction Mapping,
pubmed-meshheading:2710126-Species Specificity,
pubmed-meshheading:2710126-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene.
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pubmed:affiliation |
Graduate Program in Molecular Biology, Sloan-Kettering Institute for Cancer Research, New York, New York.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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