Linked Life Data

2708672

Source:http://linkedlifedata.com/resource/pubmed/id/2708672

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-5-26
pubmed:abstractText
This study assessed normal frequency discrimination ability in the chinchilla and determined how this ability changes as a function of an experimentally induced sensorineural hearing loss. Four chinchillas were trained by the methods of positive reinforcement to report absolute thresholds and frequency difference limens (FDLs). Subjects were then treated with the aminoglycosidic antibiotic amikacin until a 30-dB hearing loss was measured at 10.0 kHz. Absolute and frequency difference thresholds were determined during and after drug treatment. When post-drug thresholds had stabilized, subjects were sacrificed and their cochleas stained, embedded in plastic, microdissected, and viewed with phase contrast microscopy to permit examination of the cochlear tissue. Post-drug data suggest that frequency discrimination at a high frequency is unaffected by a 40- to 45-dB sensorineural hearing loss, considerable hair cell damage, and the resultant disruption of the cochlear micromechanics. The data, in concert with previously published reports, suggest that FDLs may be less affected by a high-frequency sensorineural hearing loss than by a low-frequency sensorineural hearing loss.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0001-4966
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1302-13
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Frequency difference limens in normal and sensorineural hearing impaired chinchillas.
pubmed:affiliation
Auditory Physiology Laboratory, Northwestern University, Evanston, Illinois 60201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't