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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1989-6-2
|
| pubmed:databankReference | |
| pubmed:abstractText |
We isolated cDNA clones for cytochrome P-450 genes expressed in the olfactory neuroepithelium by screening a corresponding rat cDNA library. Sequence analysis and RNA blot hybridization revealed a new cytochrome P-450, designated cytochrome P-450olf1, which is the first reported cytochrome P-450 mRNA uniquely expressed in the chemosensory organ. Cytochrome P-450olf1 shows intermediate level of sequence similarity (38-53% identity) to several liver cytochrome P-450 enzymes, suggesting that it belongs to the cytochrome P-450II family, but defines a new subfamily (cytochrome P-450IIG) within it. Cytochrome P-450II enzymes are known to process diverse organic compounds, including odorants. This, together with the specificity of cytochrome P-450olf1 to the sensory neuroepithelium, may indicate a role for this protein in olfactory reception.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
264
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6780-5
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2708343-Amino Acid Sequence,
pubmed-meshheading:2708343-Animals,
pubmed-meshheading:2708343-Base Sequence,
pubmed-meshheading:2708343-Blotting, Northern,
pubmed-meshheading:2708343-Cattle,
pubmed-meshheading:2708343-Chemoreceptor Cells,
pubmed-meshheading:2708343-Cloning, Molecular,
pubmed-meshheading:2708343-Cytochrome P-450 Enzyme System,
pubmed-meshheading:2708343-DNA,
pubmed-meshheading:2708343-Epithelium,
pubmed-meshheading:2708343-Molecular Sequence Data,
pubmed-meshheading:2708343-Multigene Family,
pubmed-meshheading:2708343-Olfactory Mucosa,
pubmed-meshheading:2708343-Rats,
pubmed-meshheading:2708343-Rats, Inbred Strains,
pubmed-meshheading:2708343-Restriction Mapping,
pubmed-meshheading:2708343-Smell,
pubmed-meshheading:2708343-Solubility,
pubmed-meshheading:2708343-Tissue Distribution
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception.
|
| pubmed:affiliation |
Department of Membrane Research, Weizmann Institute of Science, Rehovot, Israel.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|