Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-6-1
pubmed:abstractText
Pertussis toxin is produced only by strains of Bordetella pertussis. Cloned genes encoding pertussis toxin from B. pertussis were transferred into Bordetella bronchiseptica and Bordetella parapertussis by conjugation. These transconjugants expressed pertussis toxin at levels comparable to those expressed by B. pertussis. The toxin made by these strains was biologically active in the Chinese hamster cell clumping assay, contained all five subunits, and was mostly periplasmic. Toxin expression appeared to be modulated in the same way as are the vir-regulated genes of B. pertussis. Introduction of these plasmids into B. pertussis failed to produce hypertoxigenic strains. Instead, these transconjugants underwent plasmid loss, gene deletions, or conversion to the avirulent phase.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-14413273, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-14462671, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-16558081, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-18015628, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-18016337, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2438270, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2860757, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2871544, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2873570, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2877614, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2883124, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2896289, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2896826, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2897691, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-2903140, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-3549567, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-3584073, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-3704651, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-3818081, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-388356, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-3989513, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-417070, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-4342612, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-525927, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6140441, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6161559, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6282695, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6290332, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6309661, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6311749, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6315733, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6317569, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6374658, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6402488, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-6682833, http://linkedlifedata.com/resource/pubmed/commentcorrection/2707851-7043468
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1413-8
pubmed:dateRevised
2010-9-9
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Expression of pertussis toxin in Bordetella bronchiseptica and Bordetella parapertussis carrying recombinant plasmids.
pubmed:affiliation
Biologic Laboratories, Center for Disease Control of the Massachusetts Department of Public Health, Boston 02130.
pubmed:publicationType
Journal Article