Linked Life Data

2707462

Source:http://linkedlifedata.com/resource/pubmed/id/2707462

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-6-7
pubmed:abstractText
The secretion of prolactin (PRL) after intravenous metoclopramide was evaluated in six prepubertal subjects with idiopathic isolated hypogonadotropic hypogonadism before and after repeated testosterone (T) injections. The PRL response to metoclopramide was markedly blunted before T treatment, but both the basal and metoclopramide-stimulated PRL secretion became normal after 4 to 15 months of intramuscular T enanthate, although in three of the subjects, serum T was low at the time of the repeat study. These results confirm that the pituitary lactotrophs are normal in this disorder and suggest that the attenuated response observed in the untreated patients is due to the chronic and persistent exposure of the lactotrophs to an environment low in T. The effect of exogenous T on the lactotrophs persists for several weeks after T is discontinued.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0015-0282
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
855-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Metoclopramide-mediated prolactin secretion in patients with idiopathic hypogonadotropic hypogonadism: effect of testosterone therapy.
pubmed:affiliation
University of Nigeria Teaching Hospital, Enugu.
pubmed:publicationType
Journal Article