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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-6-2
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pubmed:abstractText |
Two new conjugates of 1-beta-D-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0301-472X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2707318-Animals,
pubmed-meshheading:2707318-Antineoplastic Agents,
pubmed-meshheading:2707318-Cell Division,
pubmed-meshheading:2707318-Cell Line,
pubmed-meshheading:2707318-Cytarabine,
pubmed-meshheading:2707318-Drug Administration Schedule,
pubmed-meshheading:2707318-Female,
pubmed-meshheading:2707318-Injections, Intraperitoneal,
pubmed-meshheading:2707318-Leukemia, Myeloid,
pubmed-meshheading:2707318-Mice,
pubmed-meshheading:2707318-Mice, Inbred BALB C,
pubmed-meshheading:2707318-Neoplasm Transplantation
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pubmed:year |
1989
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pubmed:articleTitle |
Therapeutic activity of 1-beta-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice.
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pubmed:affiliation |
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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